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Isotretinoin (Oral Route) Precautions - Mayo Clinic. |
Isotretinoin (Oral Route) Side Effects - Mayo Clinic.
In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below.
The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur.
Using alcohol or tobacco with certain medicines may also cause interactions to occur. Using this medicine with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.
The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:. Isotretinoin comes with a patient information form and Medication Guide. It is very important that you read and understand this information. Be sure to carefully follow these instructions and ask your doctor if you have any questions. Be sure to ask your doctor if you have any questions about this program.
It is very important that you understand and follow all of the requirements. You will not get another prescription unless you follow the instructions for the program.
Swallow the capsule whole with a full glass 8 ounces of water or other liquid. Do not crush, break, chew, or suck the capsule. It is very important that you take isotretinoin only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.
To do so may increase the chance of side effects. It is very important that you not share this medicine with anyone else because of the risk of birth defects and other serious side effects. Different brands may not work the same way. If you refill your medicine and it looks different, check with your pharmacist.
The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so. The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.
If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses. Do not take extra medicine to make up for a missed dose. Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
Keep from freezing. It is very important that your doctor check your or your child's progress at regular visits to make sure this medicine is working properly. Blood tests may be needed to check for unwanted effects. Isotretinoin causes birth defects in humans if taken during pregnancy. If you suspect that you may have become pregnant, check with your doctor right away. Using this medicine while you are pregnant can cause very serious birth defects. Use two forms of effective birth control to keep from getting pregnant 1 month before beginning treatment, while you are using this medicine even if the medicine is temporarily stopped , and for at least 1 month after you stop taking the medicine.
The most effective forms of birth control are hormone birth control pills, patches, shots, vaginal rings, or implants, an IUD, or a vasectomy for men. One of these forms of birth control should be combined with a condom, a diaphragm, or a cervical cap.
Isotretinoin must not be taken by women of reproductive age who may become pregnant unless 2 effective forms of birth control have been used for at least 1 month before the start of treatment.
Contraception must be continued during the period of treatment, which is up to 20 weeks, and for 1 month after isotretinoin is stopped. Be sure that you have discussed this information with your doctor.
If you are a woman who is able to have children, you must have 2 pregnancy tests before beginning treatment with isotretinoin to make sure you are not pregnant. The second pregnancy test must be taken at least 19 days after the first test and during the first 5 days of the menstrual period immediately before beginning treatment.
In addition, you must have a pregnancy test each month while you are using this medicine and 1 month after treatment is completed. Do not take vitamin A or any vitamin supplement containing vitamin A while using this medicine, unless otherwise directed by your doctor. During the first 3 weeks you are taking isotretinoin, your skin may become irritated.
Also, your acne may seem to get worse before it gets better. Check with your doctor if your skin condition does not improve within 1 to 2 months after starting this medicine or at any time your skin irritation becomes severe. Full improvement continues after you stop using isotretinoin and may take up to 6 months. Your doctor can help you choose the right skin products to reduce skin dryness and irritation.
You or your child should not donate blood to a blood bank while using isotretinoin or for 30 days after you stop using it. This is to prevent a pregnant patient from receiving blood that contains the medicine. In some patients, isotretinoin may cause a decrease in night vision. This problem may occur suddenly. If it does occur, do not drive or do anything else that could be dangerous until you know how this medicine affects you. Also, check with your doctor.
Isotretinoin may cause dryness of the eyes. If you or your child wear contact lenses, your eyes may be more sensitive to them during the time you are using isotretinoin and for up to 2 weeks after stopping it. To help relieve dryness of the eyes, check with your doctor about using a lubricating solution, such as artificial tears.
If eye inflammation occurs, check with your doctor right away. Isotretinoin may cause dryness of the mouth and nose.
For temporary relief of mouth dryness, use sugarless candy or gum, melt bits of ice in your mouth, or use a saliva substitute. However, if dry mouth continues for more than 2 weeks, check with your medical doctor or dentist. Continuing dryness of the mouth may increase the chance of dental disease, including tooth decay, gum disease, and fungus infections.
Avoid overexposing your skin to sunlight, wind, or cold weather. Your skin will be more prone to sunburn, dryness, or irritation, especially during the first 2 or 3 weeks of treatment. However, you or your child should not stop using this medicine unless the skin irritation becomes too severe.
Do not use a sunlamp or tanning beds. To help isotretinoin to work properly, use sunscreen or sunblock lotions with a sun protection factor SPF of at least 15 on a regular basis. Also, wear protective clothing and hats. Isotretinoin may cause some people to be agitated, irritable, or display other abnormal behaviors. Also, your acne may seem to get worse before it gets better.
Check with your doctor if your skin condition does not improve within 1 to 2 months after starting this medicine or at any time your skin irritation becomes severe. Full improvement continues after you stop using isotretinoin and may take up to 6 months. Your doctor can help you choose the right skin products to reduce skin dryness and irritation. You or your child should not donate blood to a blood bank while using isotretinoin or for 30 days after you stop using it.
This is to prevent a pregnant patient from receiving blood that contains the medicine. In some patients, isotretinoin may cause a decrease in night vision. This problem may occur suddenly. If it does occur, do not drive or do anything else that could be dangerous until you know how this medicine affects you. Also, check with your doctor.
Isotretinoin may cause dryness of the eyes. If you or your child wear contact lenses, your eyes may be more sensitive to them during the time you are using isotretinoin and for up to 2 weeks after stopping it. To help relieve dryness of the eyes, check with your doctor about using a lubricating solution, such as artificial tears.
If eye inflammation occurs, check with your doctor right away. Isotretinoin may cause dryness of the mouth and nose. For temporary relief of mouth dryness, use sugarless candy or gum, melt bits of ice in your mouth, or use a saliva substitute. However, if dry mouth continues for more than 2 weeks, check with your medical doctor or dentist.
Continuing dryness of the mouth may increase the chance of dental disease, including tooth decay, gum disease, and fungus infections. Avoid overexposing your skin to sunlight, wind, or cold weather.
Your skin will be more prone to sunburn, dryness, or irritation, especially during the first 2 or 3 weeks of treatment. However, you or your child should not stop using this medicine unless the skin irritation becomes too severe. Do not use a sunlamp or tanning beds. To help isotretinoin to work properly, use sunscreen or sunblock lotions with a sun protection factor SPF of at least 15 on a regular basis.
Also, wear protective clothing and hats. Isotretinoin may cause some people to be agitated, irritable, or display other abnormal behaviors. It may also cause some people to have suicidal thoughts and tendencies or to become more depressed.
If you, your child, or your caregiver notice any of these side effects, check with you doctor right away. This medicine may increase pressure in your head, which may lead to vision loss or serious brain problems. Check with your doctor right away if you have a bad headache, blurred vision, dizziness, nausea, vomiting, or seizures. Serious skin reactions can occur with this medicine.
Check with your doctor right away if you or your child have any of the following symptoms while using this medicine: blistering, peeling, or loosening of the skin, chills, diarrhea, itching, joint or muscle pain, rash, red skin lesions, often with a purple center, sores, ulcers, or white spots in the mouth or on the lips, or unusual tiredness or weakness.
Isotretinoin may cause bone or muscle problems, including joint pain, muscle pain or stiffness, or difficulty moving. You may get hurt more easily during rough sports. You may also heal more slowly.
If this medicine is for your child, tell the doctor if you think your child is not growing properly. It is very important that you or your child not use wax epilation to remove hair while you are taking isotretinoin and for 6 months after stopping it. Isotretinoin can increase your chance of scarring from wax epilation. It is very important that you or your child not have any cosmetic procedures to smooth your skin eg, dermabrasion, laser while you are using isotretinoin and for 6 months after stopping it.
Isotretinoin can increase your chance of scarring from these procedures. This medicine may affect blood sugar levels. If you or your child are diabetic and notice a change in the results of your blood or urine sugar tests, check with your doctor. Pancreatitis may occur while you are using this medicine. Tell your doctor right away if you or your child have sudden and severe stomach pain, chills, constipation, nausea, vomiting, fever, or lightheadedness.
Isotretinoin may cause some people to have hearing problems within a few weeks after they start using it. Check with your doctor right away if you or your child have hearing loss, a continuing ringing or buzzing, or any other unexplained noise in the ears. Check with your doctor right away if you have pain or tenderness in the upper stomach, pale stools, dark urine, loss of appetite, nausea, unusual tiredness or weakness, or yellow eyes or skin.
These could be symptoms of a serious liver problem. Tell your doctor right away if you or your child have abdominal or stomach pain, rectal bleeding, or severe diarrhea. These may be symptoms of a serious condition called inflammatory bowel disease. This medicine may cause serious allergic reactions, including anaphylaxis, which can be life-threatening and requires immediate medical attention. Call your doctor right away if you have a rash, itching, redness, soreness, or itching skin, trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth while you are using this medicine.
This reaction is more often seen in people who also have an allergy to aspirin.
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It often causes mucocutaneous, musculoskeletal, neurological, and ocular adverse effects. Most common musculoskeletal adverse effects include arthralgia and myalgia. Adverse events may be explained by immunomodulatory mechanisms and effects of retinoids on neural tissue development and differentiation, tumoral tissue growing, loss of synaptic transmission, and function. These include headache, insomnia, hearing loss, epileptic seizure, and pseudotumor cerebri.
This involvement is more prominent in sensorial nerves and myelin fibers at distal of extremities. Presence of clinical or electrophysiological peripheral neuropathy after systemic use of retinoid was reported within 10 days in earliest case, and after four years in latest case. This recovery may occur within two weeks to 2. However, authors detected a significantly decreased sensory conduction velocity and action potential amplitude in median, ulnar, and sural nerves.
These differences can be related to duration or dose of isotretinoin use. Currently, the exact mechanism of isotretinoin leading to peripheral neuropathy is unclear. In a study, it has been demonstrated that retinoid affects nerve tissue development in vivo and in vitro. Electrophysiological evaluation at sixth month revealed demyelinating polyneuropathy, being more prominent in sensorial fibers.
Electrophysiological findings were normalized two months after withdrawal from treatment. These results are in agreement with other studies which detected neuropathy. In SAPHO syndrome, constitutional symptoms, abnormal laboratory findings and musculoskeletal symptoms are observed as well as necrotizing acne. In addition, development of sacroiliitis after systemic isotretinoin treatment was also reported in patients with SAPHO syndrome. Unilateral sacroiliitis developed in patients who used isotretinoin for three months while bilateral sacroiliitis developed in patients who used isotretinoin for two years.
HLA-B27 positivity was detected in this case. Sacroiliitis developed bilaterally in our case. Sacroiliitis in our case was linked to isotretinoin use, as the patient had no musculoskeletal complaint prior to isotretinoin use. Furthermore, hip pain, back pain and active sacroiliitis findings on MRI emerged three months after prescription of isotretinoin. Isotretinoin may cause bone or muscle problems, including joint pain, muscle pain or stiffness, or difficulty moving.
You may get hurt more easily during rough sports. You may also heal more slowly. If this medicine is for your child, tell the doctor if you think your child is not growing properly.
It is very important that you or your child not use wax epilation to remove hair while you are taking isotretinoin and for 6 months after stopping it.
Isotretinoin can increase your chance of scarring from wax epilation. It is very important that you or your child not have any cosmetic procedures to smooth your skin eg, dermabrasion, laser while you are using isotretinoin and for 6 months after stopping it. Isotretinoin can increase your chance of scarring from these procedures. This medicine may affect blood sugar levels. If you or your child are diabetic and notice a change in the results of your blood or urine sugar tests, check with your doctor.
Pancreatitis may occur while you are using this medicine. Tell your doctor right away if you or your child have sudden and severe stomach pain, chills, constipation, nausea, vomiting, fever, or lightheadedness.
Isotretinoin may cause some people to have hearing problems within a few weeks after they start using it. Check with your doctor right away if you or your child have hearing loss, a continuing ringing or buzzing, or any other unexplained noise in the ears.
Check with your doctor right away if you have pain or tenderness in the upper stomach, pale stools, dark urine, loss of appetite, nausea, unusual tiredness or weakness, or yellow eyes or skin.
These could be symptoms of a serious liver problem. Tell your doctor right away if you or your child have abdominal or stomach pain, rectal bleeding, or severe diarrhea.
These may be symptoms of a serious condition called inflammatory bowel disease. This medicine may cause serious allergic reactions, including anaphylaxis, which can be life-threatening and requires immediate medical attention. Call your doctor right away if you have a rash, itching, redness, soreness, or itching skin, trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth while you are using this medicine.
This reaction is more often seen in people who also have an allergy to aspirin. This medicine lowers the number of some types of blood cells in your body. Because of this, you or your child may bleed or get infections more easily. To help with these problems, avoid being near people who are sick or have infections. Wash your hands often. Stay away from rough sports or other situations where you could be bruised, cut, or injured.
Brush and floss your teeth gently. Be careful when using sharp objects, including razors and fingernail clippers. Do not take other medicines without checking first with your doctor. This includes vitamins, herbal products, and prescription or nonprescription over-the-counter [OTC] medicines. Some medicines or nutritional supplements eg, St. John's wort may cause your birth control pills to not work as well. There is a problem with information submitted for this request.
Sign up for free, and stay up to date on research advancements, health tips and current health topics, like COVID, plus expertise on managing health. Ninety-four patients treated with isotretinoin suffering from musculoskeletal pain were included. The patients were then examined in detail.
They were also compared with healthy controls. Isotretinoin has been associated with various musculoskeletal side effects in the recent literature. Some of these are original studies, while most of them are sporadic case reports [ 1 , 2 , 9 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 ].
The onset of the musculoskeletal symptoms of the patients in these case reports was in the first few months. They have found myalgia in Acute sacroiliitis was determined in 8. The authors concluded that the incidence of sacroiliitis in patients receiving isotretinoin is quite high [ 1 ].
In our study, the percentages of myalgia and sacroiliitis were similar to this study, however, the frequency of back pain was noticeably higher in isotretinoin group. This was one of the most important results of this study. Other musculoskeletal side effects were not found to be statistically significantly related with the total cumulative dose of isotretinoin.
The patients with low back pain using isotretinoin should be asked about the dosage and duration of their drug, and if necessary, the dose should be reduced. On the other hand, it is an interesting finding that sacroiliitis is not related with the total cumulative dose of the drug.
In their study, Alkan et al. In the isotretinoin group, No inflammatory back pain was observed in tetracycline group 32 patients. They found unilateral sacroiliitis only in one patient in the isotretinoin group that included a total of 42 patients. They also emphasized that all rheumatologic symptoms of the patients disappeared after the discontinuation of the drug and the complaints were drug related [ 2 ]. In the present study, The total cumulative dose of isotretinoin does not seem to be in relationship with mechanical or inflammatory back pain.
In another study, the effect of isotretinoin on Achilles tendinopathy was investigated. The authors divided a total of sixteen rats into two groups and administered isotretinoin for the first group and soy oil for the second group.
In the isotretinoin group, a biomechanical and histopathological negative effect on Achilles tendon was detected. Therefore, the authors recommended asking the patients with tendinopathy about their use of isotretinoin in their medical history [ 9 ]. Enthesitis is a hallmark feature of the spondyloarthropathies. Although rare, enthesitis can be seen due to isotretinoin usage.
Several new MRI and ultrasound scoring systems have been used for diagnosis of enthesitis. The increased thickness of entheses and hypoechogenicity are the specific ultrasonographic findings of the enthesitis [ 22 , 31 ]. In our study, the diagnosis of enthesitis was based on solely clinical examination.
Only four patients 4. Since tendinopathy can be seen in patients receiving isotretinoin, such patients should be asked whether they use the drug or not [ 9 ]. The exact pathogenesis of sacroiliitis in isotretinoin use is unclear. This leads to a degeneration process in the synovial cells. Retinol and retinoic acid derivatives such as isotretinoin can also stimulate MMP-2 activity and cause membrane damage in the joints [ 8 , 12 , 32 , 33 ]. It is believed that isotretinoin treatment may render cells susceptible to mild traumas that normally would not cause injury.
This theory is supported by studies of the presence of sacroiliitis in athletes treated with isotretinoin [ 8 , 32 , 34 ]. Weber et al. MRI scans were examined by three readers, independently. Bone marrow edema edema and fat metaplasia were observed in both groups but these lesions did not increase after running. They said that these MRI findings could be reflective of mechanical stress injury, vascular signals, anatomic variants, or degenerative joint disease [ 34 ].
The limited extent bone marrow edema of sacroiliac joints is quite unspecific and can occur in various conditions, not related to axial spondyloarthropathy. Winter et al. In our study, all of the patients were young and physically active. Bone marrow edema consistent with sacroiliitis was observed in It may be an overdiagnosis of sacroiliitis, for this reason, this results should be interpreted with caution. Our patients were symptomatic after using isotretinoin which suggest the hypothesis of drug related sacroiliitis, in addition, MRI follow up to confirm resolution is recommended.
Taheri et al. The authors reported that Of the patients with back pain, Sacroiliitis was determined only in 5 patients [ 10 ]. This study have more patients but no control group. In addition, they assessed only the incidence of low back pain and sacroiliitis but not arthralgia, myalgia, tendinopathy or enthesopathy. Similarly to our study, inflammatory back pain without sacroiliitis was found in the majority of the patients.
It can be claimed that the drug may cause inflammatory back pain without sacroiliitis in healthy subjects. However in our study, numbers of the patients with mechanical back pain were more higher than inflammatory back pain.
We showed that mechanical low back pain is a common complication in patients receiving isotretinoin. We recommend that young patients with back pain be questioned about their drug usage, and clinicians need to be aware about this complaint may result from isotretinoin.
In healthy control group, only a few of the volunteers had musculoskeletal pain symptoms such as myalgia, arhtralgia and back pain. None of them had sacroiliitis or tendinopathy. The statistically significant high prevalence of musculoskeletal findings in drug users in the same age group was considered as an important indicator that current symptoms were significantly drug dependent.
This study has some limitations. There is a limited number of patients in total, so the results of the study should be interpreted carefully. Another limitation was that the MRI images of the patients with sacroiliitis were not scored. Furthermore, MRI follow up may be recommended for sacroiliitis positive patients to confirm resolution after drug cessation.
Enthesitis was not evaluated and scored by an imaging method such as ultrasonography or MRI in our study. The diagnosis of enthesitis was depended on solely clinical evaluation. Further randomized controlled studies are needed with wider patient groups in order to elucidate the musculoskeletal side effects of the isotretinoin.
Low back pain is a very common side effect of isotretinoin and it is dose-related. Although sacroiliitis is a rare complication of isotretinoin, inflammatory back pain without sacroiliitis can be seen frequently. The patients suffering from back pain should be asked for drug usage. Considering that musculoskeletal complaints are mostly temporary, they can be often overlooked by clinicians. For this reason, we recommend the clinicians to perform a more careful and close follow-up in order to carry out the most proper approach to these patients.
The prevalence of sacroiliitis in patients with acne vulgaris using isotretinoin. Cutan Ocul Toxicol. Article Google Scholar. Isotretinoin-induced spondyloarthropathy-related symptoms: a prospective study. J Rheumatol. Clin Dermatol. PubMed Article Google Scholar. Ganceviciene R, Zouboulis CC. Isotretinoin: state of the art treatment for acne vulgaris. J Dtsch Dermatol Ges. Kaplan G, Haettich B. Rheumatological symptoms due to retinoids. Baillieres Clin Rheumatol. Acute hip monoarthritis in a patient treated with isotretinoin.
J Clin Rheumatol. Nesher G, Zuckner J. Rheumatological complications of vitamin a and retinoids. Semin Arthritis Rheum. Hughes RA. Arthritis precipitated by isotretinoin treatment for acne vulgaris. Isotretinoin induced achilles tendinopathy: histopathological and biomechanical evaluation on rats. Acta Orthop Traumatol Turc. Incidence of low back pain and sacroiliitis in military families with acne vulgaris under isotretinoin therapy.
Drug information provided by: IBM Micromedex. It is very important that your doctor check your or your child's progress at regular visits to make sure this medicine is working properly. Blood tests may be needed to check for unwanted effects. Isotretinoin causes birth defects in humans if taken during pregnancy.
If you suspect that you may have become pregnant, check with your doctor right away. Using this medicine while you are pregnant can cause very serious birth defects. Use two forms of effective birth control to keep from getting pregnant 1 month before beginning treatment, while you are using this medicine even if the medicine is temporarily stoppedand for at least 1 month after you stop taking the medicine.
The most effective forms of birth control are hormone birth control pills, patches, shots, vaginal rings, or implants, an IUD, or a vasectomy for men. One of these forms of birth control should be combined with a condom, a diaphragm, or a cervical cap. Isotretinoin must not be taken by women of reproductive age who may become pregnant unless 2 effective forms of birth control have been used for at least 1 month before the start of treatment.
Contraception must be continued during the period of treatment, which is up to 20 weeks, and for 1 month after isotretinoin is stopped. Be sure that you have discussed this information with your doctor. If you are a woman who is able to have children, you must have 2 pregnancy tests before beginning treatment with isotretinoin to make sure you are not pregnant.
The second pregnancy test must be taken at least 19 days after the first test and during the first 5 days of the menstrual period immediately before beginning treatment. In addition, you must have a pregnancy test each month while you are using this medicine and 1 month after treatment is completed. Do not take vitamin A or any vitamin supplement containing vitamin A while using this medicine, unless otherwise directed by your doctor.
To do so may increase the chance of side effects. During the first 3 weeks you are taking isotretinoin, your skin may become irritated. Also, your acne may seem to get worse before it gets better. Check with your doctor if your skin condition does not improve within 1 to 2 months after starting this medicine or at any time your skin irritation becomes severe. Full improvement continues after you stop using isotretinoin and may take up to 6 months.
Your doctor can help you choose the right skin products to reduce skin dryness and irritation. You or your child should not donate blood to a blood bank while using isotretinoin or for 30 days after you stop using it.
This is to prevent a pregnant patient from receiving blood that contains the medicine. In some patients, isotretinoin may cause a decrease in night vision. This problem may occur suddenly. If it does occur, do not drive or do anything else that could be dangerous until you know how this medicine affects you.
Also, check with your doctor. Isotretinoin may cause dryness of the eyes. If you or your child wear contact lenses, your eyes may be more sensitive to them during the time you are using isotretinoin and for up to 2 weeks after stopping it.
To help relieve dryness of the eyes, check with your doctor about using a lubricating solution, such as artificial tears. If eye inflammation occurs, check with your doctor right away. Isotretinoin may cause dryness of the mouth and nose. For temporary relief of mouth dryness, use sugarless candy or gum, melt bits of ice in your mouth, or use a saliva substitute.
However, if dry mouth continues for more than 2 weeks, check with your medical doctor or dentist. Continuing dryness of the mouth may increase the chance of dental disease, including tooth decay, gum disease, and fungus infections. Avoid overexposing your skin to sunlight, wind, or cold weather.
Your skin will be more prone to sunburn, dryness, or irritation, especially during the first 2 or 3 weeks of treatment. However, you or your child should not stop using this medicine unless the skin irritation becomes too severe. Do not use a sunlamp or tanning beds. To help isotretinoin to work properly, use sunscreen or sunblock lotions with a sun protection factor SPF of at least 15 on a regular basis. Also, wear protective clothing and hats. Isotretinoin may cause some people to be agitated, irritable, or display other abnormal behaviors.
It may also cause some people to have suicidal thoughts and tendencies or to become more depressed. If you, your child, or your caregiver notice any of these side effects, check with you doctor right away. This medicine may increase pressure in your head, which may lead to vision loss or serious brain problems.
Check with your doctor right away if you have a bad headache, blurred vision, dizziness, nausea, vomiting, or seizures. Serious skin reactions can occur with this medicine. Check with your doctor right away if you or your child have any of the following symptoms while using this medicine: blistering, peeling, or loosening of the skin, chills, diarrhea, itching, joint or muscle pain, rash, red skin lesions, often with a purple center, sores, ulcers, or white spots in the mouth or on the lips, or unusual tiredness or weakness.
Isotretinoin may cause bone or muscle problems, including joint pain, muscle pain or stiffness, or difficulty moving. You may get hurt more easily during rough sports. You may also heal more slowly. If this medicine is for your child, tell the doctor if you think your child is not growing properly. It is very important that you or your child not use wax epilation to remove hair while you are taking isotretinoin and for 6 months after stopping it.
Isotretinoin can increase your chance of scarring from wax epilation. It is very important that you or your child not have any cosmetic procedures to smooth your skin eg, dermabrasion, laser while you are using isotretinoin and for 6 months after stopping it.
Isotretinoin can increase your chance of scarring from these procedures. This medicine may affect blood sugar levels.
If you or your child are diabetic and notice a change in the results of your blood or urine sugar tests, check with your doctor. Pancreatitis may occur while you are using this medicine. Tell your doctor right away if you or your child have sudden and severe stomach pain, chills, constipation, nausea, vomiting, fever, or lightheadedness. Isotretinoin may cause some people to have hearing problems within a few weeks after they start using it.
Check with your doctor right away if you or your child have hearing loss, a continuing ringing or buzzing, or any other unexplained noise in the ears. Check with your doctor right away if you have pain or tenderness in the upper stomach, pale stools, dark urine, loss of appetite, nausea, unusual tiredness or weakness, or yellow eyes or skin.
These could be symptoms of a serious liver problem. Tell your doctor right away if you or your child have abdominal or stomach pain, rectal bleeding, or severe diarrhea. These may be symptoms of a serious condition called inflammatory bowel disease. This medicine may cause serious allergic reactions, including anaphylaxis, which can be life-threatening and requires immediate medical attention.
Call your doctor right away if you have a rash, itching, redness, soreness, or itching skin, trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth while you are using this medicine.
This reaction is more often seen in people who also have an allergy to aspirin. This medicine lowers the number of some types of blood cells in your body. Because of this, you or your child may bleed or get infections more easily.
To help with these problems, avoid being near people who are sick or have infections. Wash your hands often. Stay away from rough sports or other situations where you could be bruised, cut, or injured. Brush and floss your teeth gently. Be careful when using sharp objects, including razors and fingernail clippers. Do not take other medicines without checking first with your doctor. This includes vitamins, herbal products, and prescription or nonprescription over-the-counter [OTC] medicines.
Some medicines or nutritional supplements eg, St. John's wort may cause your birth control pills to not work as well. There is a problem with information submitted for this request.
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See more conditions. Drugs and Supplements Isotretinoin Oral Route.
Low back pain is one of the very common complications of isotretinoin. It can be mostly mechanical or inflammatory. Isotretinoin-induced low. Although most musculoskeletal side effects of ISO are common, including myalgia, arthralgia, and back pain, sacroiliitis is one of the. Isotretinoin has been reported to induce inflammatory back pain (IBP) and sacroiliitis in the patients with acne vulgaris. The aim of this study. NHS medicines information on side effects of isotretinoin capsules and what you can do to cope. Back pain and aches and pains in muscles or joints. Questions about Accutane and back pain, with answers from board-certified doctors. Get all of your questions answered on RealSelf. Brush and floss your teeth gently. Copy to clipboard.Back to Isotretinoin capsules Roaccutane. Like all medicines, isotretinoin capsules can cause side effects, although not everyone gets them. Side effects will usually go away when you stop treatment. These common side effects of isotretinoin capsules happen in more than 1 in people. There are things you can do to help you cope with them:.
Apply a moisturiser cream or ointment and lip balm regularly speak to a pharmacist or your doctor about the best type to use.
Avoid using exfoliating products or anti-acne products. Try applying a thin layer of Vaseline to the inside edges of your nose. Ask your pharmacist or optician to recommend some eye drops. If you wear contact lenses and these become uncomfortable, you might have to wear glasses instead while you're taking this medicine. You may notice your skin becoming more fragile and getting redder, and it may be more sensitive to sunlight.
Do not have any cosmetic treatments, including hair removal waxing , dermabrasion, or laser treatments while you're taking isotretinoin, and for 6 months after you stop taking it. Stay out of the sun as much as possible and use a high factor sun cream SPF 15 or above before you go outside, even on cloudy days.
Do not use a sunlamp or sunbeds. Gargle with salt water adults only , drink plenty of water, eat soft food, avoid smoking or smoky places, suck ice cubes or ice lollies. Speak to a pharmacist about other ways to relieve the pain, such as painkillers, medicated lozenges or anaesthetic sprays. Make sure you rest and drink plenty of fluids. Do not drink too much alcohol. Ask your pharmacist to recommend a painkiller. Talk to your doctor if the headaches last longer than a week or are severe.
Light exercise should not be a problem, but cut down on or avoid intense exercise and physical activity as it may make joint or muscle pain worse, particularly in children and teenagers. Speak to a doctor or pharmacist if the advice on how to cope does not help and a side effect is still bothering you or does not go away. Serious side effects are usually rare and happen in less than 1 in 1, people. Stop taking isotretinoin capsules and call a doctor or contact straight away if:.
Go to In rare cases, it's possible to have a serious allergic reaction anaphylaxis to isotretinoin capsules. You could be having a serious allergic reaction and may need immediate treatment in hospital. These are not all the side effects of isotretinoin capsules. For a full list, see the leaflet inside your medicines packet. Page last reviewed: 25 February Next review due: 25 February Side effects of isotretinoin capsules. Common side effects These common side effects of isotretinoin capsules happen in more than 1 in people.
There are things you can do to help you cope with them: Dry skin, eyes, nose or lips Apply a moisturiser cream or ointment and lip balm regularly speak to a pharmacist or your doctor about the best type to use. Information: You can report any suspected side effect using the Yellow Card safety scheme. Visit Yellow Card for further information.
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