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Accutane and tooth decay.Will Accutane Cause Me to Get Cavities?
Background: Isotretinoin is the most effective therapy to treat severe acne vulgaris and its systemic adverse effects have been well documented, but little is known on dental side effects over the course of treatment. Objectives: This prospective case-control study aimed to evaluate the oral adverse effects of isotretinoin in Turkish patients with acne vulgaris; compare oral conditions between patients and normal controls; and investigate the association between salivary parameters and International Caries Detection and Assessment System ICDAS scores.
Both groups were examined before the study and at 6 months for salivary flow, buffer capacity, microbiologic tests, and caries status based on the ICDAS.
Data were statistically analyzed by the Mann—Whitney U test, Wilcoxon signed rank tests, and McNemar's Chi-square tests P Results: Twenty-two isotretinoin-treated patients and 18 controls completed the study.
Stimulated salivary parameters in both groups were not correlated significantly with the ICDAS scores. Conclusions: Isotretinoin significantly affected salivary flow, buffer capacity, caries lesion activity scores for 6 months.
However, salivary parameters and caries lesion activity scores had no significant correlations. Keywords: Acne vulgaris, dental caries, International Caries Detection and Assessment System, isotretinoin, salivary flow. Purdy S, Deberker D. Acne vulgaris. BMJ Clin Evid ; Lancet ; Minocycline for acne vulgaris: Efficacy and safety. A retrospective analysis of the duration of oral antibiotic therapy for the treatment of acne among adolescents: Investigating practice gaps and potential cost-savings.
J Am Acad Dermatol ; Scully C. Drug effects on salivary glands: Dry mouth. Oral Dis ; Effect of oral isotretinoin therapy on saliva volume and composition. Br J Dermatol ; Systemic oral isotretinoin therapy and flow rate, pH, and matrix metalloproteinase-9 activity of stimulated saliva. Acta Odontol Scand ; Reduced salivary flow induced by systemic isotretinoin may lead to dental decay. A prospective clinical study.
Dermatology ; Stookey GK. The effect of saliva on dental caries. Evaluation of flow rate, pH, Buffering capacity, calcium, total proteins and total antioxidant capacity levels of saliva in caries free and caries active children: An in vivo study. Indian J Clin Biochem ; Rugg-Gunn A. Dental caries: Strategies to control this preventable disease. Acta Med Acad ; A review of saliva: Normal composition, flow, and function.
J Prosthet Dent ; Salivary factors affecting dental erosion in children. Caries Res ; An in vivo investigation of associations between saliva properties, caries prevalence and potential lesion activity in an adult UK population. J Dent ; For debate: Problems with the DMF index pertinent to dental caries data analysis. Community Dent Oral Epidemiol ; Pitts N.
Community Dent Health ; Dietary habits and oral health related behaviors in relation to DMFT indexes of a group of young adult patients attending a dental school. The measurement of observer agreement for categorical data. Biometrics ; Quantitative assessment for stimulated saliva flow rate and buffering capacity in relation to different ages. Relationship between quantitative assessments of salivary buffering capacity and ion activity product for hydroxyapatite in relation to cariogenic potential.
Aust Dent J ; Salivary buffer capacity in relation to menarche and progesterone levels in saliva from adolescent girls: A longitudinal study. Sreebny LM. Saliva in health and disease: An appraisal and update. Int Dent J ; Salivary hypofunction and xerostomia: Diagnosis and treatment. Dent Clin North Am ; Oral side effects of isotretinoin chronic intake. N Y State Dent J ; Evaluation of the effect of isotretinoin on salivary gland function by Tcm pertechnetate imaging in acne vulgaris patients.
Turk J Med Sci ; Tenovuo J. Salivary parameters of relevance for assessing caries activity in individuals and populations. Critical pH in resting and stimulated whole saliva in groups of children and adults.
Int J Paediatr Dent ; Balkan Med J ; Users Online: Year : Volume : 20 Issue : 7 Page : The oral adverse effects of isotretinoin treatment in acne vulgaris patients: A prospective, case—control study. Niger J Clin Pract ; Niger J Clin Pract [serial online] [cited Oct 18]; Materials and Methods. Table 1: Characteristics and significance of the test and control group patients at baseline Click here to view.
Figure 1: The flow chart of the study Click here to view. Table 2: Comparison and significance of pathogen counts St. Mutans and Lactobacillus for the test and control group patients Click here to view. Table 3: Significance and differences between end and baseline of the test and control group patients according to the parameters for ICDAS scores, Salivary Flow and pH Click here to view.
Table 4: Change of salivary flow, buffer capacity and significance between groups Click here to view. Table 5: Spearman's rank correlation test results and significance between the salivary parameters, ICDAS scores as a proportion with respect to both groups for each evaluation period Click here to view. Table 6: The results of the enter method logistic regression analyses Click here to view. This article has been cited by. Related articles Acne vulgaris dental caries International Caries Detection and Assessment System isotretinoin salivary flow.
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Be sure that you have discussed this information with your doctor. If you are a woman who is able to have children, you must have 2 pregnancy tests before beginning treatment with isotretinoin to make sure you are not pregnant. The second pregnancy test must be taken at least 19 days after the first test and during the first 5 days of the menstrual period immediately before beginning treatment.
In addition, you must have a pregnancy test each month while you are using this medicine and 1 month after treatment is completed. Do not take vitamin A or any vitamin supplement containing vitamin A while using this medicine, unless otherwise directed by your doctor. To do so may increase the chance of side effects. During the first 3 weeks you are taking isotretinoin, your skin may become irritated. Also, your acne may seem to get worse before it gets better. Check with your doctor if your skin condition does not improve within 1 to 2 months after starting this medicine or at any time your skin irritation becomes severe.
Full improvement continues after you stop using isotretinoin and may take up to 6 months. Your doctor can help you choose the right skin products to reduce skin dryness and irritation. You or your child should not donate blood to a blood bank while using isotretinoin or for 30 days after you stop using it. This is to prevent a pregnant patient from receiving blood that contains the medicine. In some patients, isotretinoin may cause a decrease in night vision. This problem may occur suddenly.
If it does occur, do not drive or do anything else that could be dangerous until you know how this medicine affects you. Also, check with your doctor. Isotretinoin may cause dryness of the eyes. If you or your child wear contact lenses, your eyes may be more sensitive to them during the time you are using isotretinoin and for up to 2 weeks after stopping it. To help relieve dryness of the eyes, check with your doctor about using a lubricating solution, such as artificial tears.
If eye inflammation occurs, check with your doctor right away. Isotretinoin may cause dryness of the mouth and nose. For temporary relief of mouth dryness, use sugarless candy or gum, melt bits of ice in your mouth, or use a saliva substitute. However, if dry mouth continues for more than 2 weeks, check with your medical doctor or dentist.
Continuing dryness of the mouth may increase the chance of dental disease, including tooth decay, gum disease, and fungus infections. Avoid overexposing your skin to sunlight, wind, or cold weather. Conclusions: Isotretinoin significantly affected salivary flow, buffer capacity, caries lesion activity scores for 6 months. However, salivary parameters and caries lesion activity scores had no significant correlations.
Keywords: Acne vulgaris, dental caries, International Caries Detection and Assessment System, isotretinoin, salivary flow. Purdy S, Deberker D. Acne vulgaris. BMJ Clin Evid ; Lancet ; Minocycline for acne vulgaris: Efficacy and safety.
A retrospective analysis of the duration of oral antibiotic therapy for the treatment of acne among adolescents: Investigating practice gaps and potential cost-savings. J Am Acad Dermatol ; Scully C. Drug effects on salivary glands: Dry mouth. Oral Dis ; Effect of oral isotretinoin therapy on saliva volume and composition. Br J Dermatol ; Systemic oral isotretinoin therapy and flow rate, pH, and matrix metalloproteinase-9 activity of stimulated saliva.
Acta Odontol Scand ; Reduced salivary flow induced by systemic isotretinoin may lead to dental decay. A prospective clinical study. Dermatology ; None of the oral parameters varied with time in the control group, whereas the DMFT significantly increased in the treated group 3. Conclusions: This study clearly showed that patients treated with isotretinoin experienced oral side effects.
Abstract Background: The adverse effects of isotretinoin have been well documented, but dental side effects over the course of treatment have never been studied. For more details on how Accutane may affect your oral health, contact our Denver and Lakewood, Colorado area dental office today at Skip to content.
Request an Appointment. What You need to Know Contact Mile High Smiles For more details on how Accutane may affect your oral health, contact our Denver and Lakewood, Colorado area dental office today at Are You a New Patient?
Drug information provided by: IBM Micromedex. It is very important that your doctor check your or your child's progress at regular visits to make sure this medicine is working properly. Blood tests may be needed to check for unwanted effects. Isotretinoin causes birth defects in humans if taken during pregnancy. If you suspect that you may have become pregnant, check with your doctor right away. Using this medicine while you are pregnant can cause very serious birth defects.
Use two forms of effective birth control to keep from getting pregnant 1 month before beginning treatment, while you are using this medicine even if the medicine is temporarily stoppedand for at least 1 month after you stop taking the medicine.
The most effective forms of birth control are hormone birth control pills, patches, shots, vaginal rings, or implants, an IUD, or a vasectomy for men. One of these forms of birth control should be combined with a condom, a diaphragm, or a cervical cap. Isotretinoin must not be taken by women of reproductive age who may become pregnant unless 2 effective forms of birth control have been used for at least 1 month before the start of treatment. Contraception must be continued during the period of treatment, which is up to 20 weeks, and for 1 month after isotretinoin is stopped.
Be sure that you have discussed this information with your doctor. If you are a woman who is able to have children, you must have 2 pregnancy tests before beginning treatment with isotretinoin to make sure you are not pregnant.
The second pregnancy test must be taken at least 19 days after the first test and during the first 5 days of the menstrual period immediately before beginning treatment. In addition, you must have a pregnancy test each month while you are using this medicine and 1 month after treatment is completed. Do not take vitamin A or any vitamin supplement containing vitamin A while using this medicine, unless otherwise directed by your doctor. To do so may increase the chance of side effects. During the first 3 weeks you are taking isotretinoin, your skin may become irritated.
Also, your acne may seem to get worse before it gets better. Check with your doctor if your skin condition does not improve within 1 to 2 months after starting this medicine or at any time your skin irritation becomes severe. Full improvement continues after you stop using isotretinoin and may take up to 6 months.
Your doctor can help you choose the right skin products to reduce skin dryness and irritation. You or your child should not donate blood to a blood bank while using isotretinoin or for 30 days after you stop using it.
This is to prevent a pregnant patient from receiving blood that contains the medicine. In some patients, isotretinoin may cause a decrease in night vision. This problem may occur suddenly. If it does occur, do not drive or do anything else that could be dangerous until you know how this medicine affects you. Also, check with your doctor. Isotretinoin may cause dryness of the eyes. If you or your child wear contact lenses, your eyes may be more sensitive to them during the time you are using isotretinoin and for up to 2 weeks after stopping it.
To help relieve dryness of the eyes, check with your doctor about using a lubricating solution, such as artificial tears. If eye inflammation occurs, check with your doctor right away.
Isotretinoin may cause dryness of the mouth and nose. For temporary relief of mouth dryness, use sugarless candy or gum, melt bits of ice in your mouth, or use a saliva substitute.
However, if dry mouth continues for more than 2 weeks, check with your medical doctor or dentist. Continuing dryness of the mouth may increase the chance of dental disease, including tooth decay, gum disease, and fungus infections. Avoid overexposing your skin to sunlight, wind, or cold weather.
Your skin will be more prone to sunburn, dryness, or irritation, especially during the first 2 or 3 weeks of treatment. However, you or your child should not stop using this medicine unless the skin irritation becomes too severe. Do not use a sunlamp or tanning beds. To help isotretinoin to work properly, use sunscreen or sunblock lotions with a sun protection factor SPF of at least 15 on a regular basis.
Also, wear protective clothing and hats. Isotretinoin may cause some people to be agitated, irritable, or display other abnormal behaviors. It may also cause some people to have suicidal thoughts and tendencies or to become more depressed.
If you, your child, or your caregiver notice any of these side effects, check with you doctor right away. This medicine may increase pressure in your head, which may lead to vision loss or serious brain problems. Check with your doctor right away if you have a bad headache, blurred vision, dizziness, nausea, vomiting, or seizures. Serious skin reactions can occur with this medicine. Check with your doctor right away if you or your child have any of the following symptoms while using this medicine: blistering, peeling, or loosening of the skin, chills, diarrhea, itching, joint or muscle pain, rash, red skin lesions, often with a purple center, sores, ulcers, or white spots in the mouth or on the lips, or unusual tiredness or weakness.
Isotretinoin may cause bone or muscle problems, including joint pain, muscle pain or stiffness, or difficulty moving. You may get hurt more easily during rough sports. You may also heal more slowly. If this medicine is for your child, tell the doctor if you think your child is not growing properly. It is very important that you or your child not use wax epilation to remove hair while you are taking isotretinoin and for 6 months after stopping it.
Isotretinoin can increase your chance of scarring from wax epilation. It is very important that you or your child not have any cosmetic procedures to smooth your skin eg, dermabrasion, laser while you are using isotretinoin and for 6 months after stopping it. Isotretinoin can increase your chance of scarring from these procedures.
This medicine may affect blood sugar levels. If you or your child are diabetic and notice a change in the results of your blood or urine sugar tests, check with your doctor. Pancreatitis may occur while you are using this medicine. Tell your doctor right away if you or your child have sudden and severe stomach pain, chills, constipation, nausea, vomiting, fever, or lightheadedness.
Isotretinoin may cause some people to have hearing problems within a few weeks after they start using it. Check with your doctor right away if you or your child have hearing loss, a continuing ringing or buzzing, or any other unexplained noise in the ears. Check with your doctor right away if you have pain or tenderness in the upper stomach, pale stools, dark urine, loss of appetite, nausea, unusual tiredness or weakness, or yellow eyes or skin.
These could be symptoms of a serious liver problem. Tell your doctor right away if you or your child have abdominal or stomach pain, rectal bleeding, or severe diarrhea. These may be symptoms of a serious condition called inflammatory bowel disease. This medicine may cause serious allergic reactions, including anaphylaxis, which can be life-threatening and requires immediate medical attention. Call your doctor right away if you have a rash, itching, redness, soreness, or itching skin, trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth while you are using this medicine.
This reaction is more often seen in people who also have an allergy to aspirin. This medicine lowers the number of some types of blood cells in your body. Because of this, you or your child may bleed or get infections more easily. To help with these problems, avoid being near people who are sick or have infections. Wash your hands often. Stay away from rough sports or other situations where you could be bruised, cut, or injured.
Brush and floss your teeth gently. Be careful when using sharp objects, including razors and fingernail clippers. Do not take other medicines without checking first with your doctor. This includes vitamins, herbal products, and prescription or nonprescription over-the-counter [OTC] medicines. Some medicines or nutritional supplements eg, St. John's wort may cause your birth control pills to not work as well. There is a problem with information submitted for this request.
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Reduced salivary flow induced by systemic isotretinoin may lead to dental decay. A prospective clinical study Dermatology. ;(3) doi: /. Background: Isotretinoin is the most effective therapy to treat severe acne vulgaris and its systemic adverse effects have been well documented, but little is. Medications that alter salivary flow are a recognized risk factor for dental caries. The decayed-missed-filled teeth (DMFT) index is a classic. Background: The adverse effects of isotretinoin have been well documented, Keywords: Decayed, missing and filled teethDental. Since Accutane may cause dryness in the mouth, it can increase the risk of cavities and gum disease. Therefore, if you are taking Accutane and experience. For temporary relief of mouth dryness, use sugarless candy or gum, melt bits of ice in your mouth, or use a saliva substitute. Dent Clin North Am ; The effect of saliva on dental caries. Table 6: The results of the enter method logistic regression analyses Click here to view.Background: The adverse effects of isotretinoin have been well documented, but dental side effects over the course of treatment have never been studied. Objectives: To prospectively document the oral side effects experienced by a group of patients taking isotretinoin and to compare the changes in oral health and salivary parameters with a control group.
Methods: A cohort study was conducted within the dermatology department at the University Hospital in collaboration with two private dermatology practices in Nice, France. Patients were treated at a dose of 0. The control group was made up of students from the University of Nice-Sophia-Antipolis.
The salivary flow, the buffer capacity of saliva, the number of pathogen bacteria and the DMFT index number of decayed, missing and filled teeth were assessed at each visit. Results: Eighteen patients and 99 controls were available for evaluation. None of the oral parameters varied with time in the control group, whereas the DMFT significantly increased in the treated group 3.
Conclusions: This study clearly showed that patients treated with isotretinoin experienced oral side effects. Abstract Background: The adverse effects of isotretinoin have been well documented, but dental side effects over the course of treatment have never been studied. Publication types Research Support, Non-U.
Substances Dermatologic Agents Isotretinoin.
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